Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 5.821


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_748152330.692.9e-03Click!
FOSBchr19_+_506630890.552.6e-02Click!
FOSL1chr11_-_654244360.381.4e-01Click!
JUNDchr19_-_18253436-0.371.6e-01Click!
JUNBchr19_+_12763295-0.048.8e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_19706979 37.088 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_-_177378801 35.212 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_+_181421984 31.719 LAMC2
laminin, gamma 2
chr12_+_13240868 26.448 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240983 25.026 EMP1
epithelial membrane protein 1
chr12_+_13240987 24.884 EMP1
epithelial membrane protein 1
chr1_+_221955876 24.314 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr3_-_152517204 22.809 NM_023915
GPR87
G protein-coupled receptor 87
chr3_+_11153778 22.175 NM_001098213
HRH1
histamine receptor H1
chr7_+_116099648 21.703 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr1_+_181421796 21.652 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr10_-_88720908 21.276 LOC100133190
hypothetical LOC100133190
chr1_+_181422016 20.754 LAMC2
laminin, gamma 2
chr20_-_17487480 19.878 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr10_+_24795465 19.577 KIAA1217
KIAA1217
chr10_+_24795446 19.009 KIAA1217
KIAA1217
chr5_+_145297490 17.451 SH3RF2
SH3 domain containing ring finger 2
chr6_+_47774247 17.122 NM_153838
GPR115
G protein-coupled receptor 115
chr11_+_101488380 16.975 NM_001195045
YAP1
Yes-associated protein 1
chr18_+_59295123 16.939 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_-_104507862 16.521 AHNAK2
AHNAK nucleoprotein 2
chr21_+_29439768 16.419 C21orf7
chromosome 21 open reading frame 7
chr17_-_36996611 15.353 NM_000526
KRT14
keratin 14
chr1_-_94779727 15.208 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_207891264 15.102 NM_001017402
LAMB3
laminin, beta 3
chr6_+_31190505 14.968 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr5_+_150000394 14.625 NM_001109974
NM_007286
SYNPO

synaptopodin

chr20_+_19903778 14.345 RIN2
Ras and Rab interactor 2
chr8_-_38505331 14.174 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr11_-_65860450 14.011 NM_004292
RIN1
Ras and Rab interactor 1
chr12_-_51173238 13.937 NM_005554
KRT6A
keratin 6A
chr9_+_102231616 13.322 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr4_+_108965167 12.993 NM_001136258
SGMS2
sphingomyelin synthase 2
chr15_+_38319326 12.713 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_-_152744143 12.694 SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_+_183302105 12.688 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr18_+_59593591 12.570 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr4_-_115120251 12.412 NM_024590
ARSJ
arylsulfatase family, member J
chr1_+_154351082 12.047 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr6_-_152744022 11.828 SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_129381086 11.693 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr10_+_118177371 11.688 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr3_-_150578103 11.683 TM4SF1
transmembrane 4 L six family member 1
chr1_+_34993234 11.629 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr17_-_7962531 11.586 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr3_-_150578207 11.265 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_-_56445653 11.073 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr4_+_169989680 11.021 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr3_-_150578148 11.002 TM4SF1
transmembrane 4 L six family member 1
chr1_-_205272619 10.949 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr17_-_37022465 10.823 NM_005557
KRT16
keratin 16
chr14_+_51025604 10.763 NM_001042481
FRMD6
FERM domain containing 6
chr11_-_6298284 10.588 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr19_+_43486640 10.507 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr14_+_104218487 10.485


chr11_-_117640166 10.358 MPZL2
myelin protein zero-like 2
chr3_-_150578023 10.230 TM4SF1
transmembrane 4 L six family member 1
chr3_-_11585264 10.124 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr1_-_36589744 10.109


chr1_-_115682374 10.108 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr1_+_27062215 10.015 NM_006142
SFN
stratifin
chr7_-_42243142 9.998 NM_000168
GLI3
GLI family zinc finger 3
chr8_+_22900863 9.956 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr7_+_838663 9.920 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr6_-_10527772 9.852 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_138470160 9.743 NM_022121
PERP
PERP, TP53 apoptosis effector
chr17_-_37034288 9.730 NM_000422
KRT17
keratin 17
chr17_-_7434113 9.657 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr7_+_28692122 9.618 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr11_-_117640078 9.496


chr3_+_30623376 9.413 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr2_-_65447267 9.375 SPRED2
sprouty-related, EVH1 domain containing 2
chr3_+_30622905 9.321 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr15_-_38417564 9.174 C15orf52
chromosome 15 open reading frame 52
chr1_+_154351200 9.153 LMNA
lamin A/C
chr9_+_676640 9.140


chr18_+_50646616 9.107 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr12_+_10256682 9.044 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr7_-_42243318 9.022 GLI3
GLI family zinc finger 3
chr8_+_120289735 9.014 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr19_-_56215084 8.970 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr2_+_113591940 8.960 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr11_-_117640196 8.839 MPZL2
myelin protein zero-like 2
chr6_+_41712907 8.824 MDFI
MyoD family inhibitor
chr1_+_24518501 8.784 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr18_+_54039818 8.743 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_-_90456824 8.577 NM_001100111
LOC286238
hypothetical protein LOC286238
chr20_-_35586366 8.553 NM_001167823
BLCAP
bladder cancer associated protein
chr5_+_145296313 8.542 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr1_+_154351162 8.527 LMNA
lamin A/C
chr2_-_166359016 8.477 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr6_+_74462654 8.454 CD109
CD109 molecule
chr19_-_43955984 8.358 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr3_-_48607596 8.281 NM_000094
COL7A1
collagen, type VII, alpha 1
chr18_+_54039779 8.274 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr16_+_56219802 8.254 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr3_+_57069508 8.244 NM_181727
SPATA12
spermatogenesis associated 12
chr1_-_108032645 8.100 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr2_-_65447370 7.998 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr19_-_52427698 7.941 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chrX_+_99786044 7.879 SRPX2
sushi-repeat containing protein, X-linked 2
chr18_+_54039730 7.875 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_-_116920232 7.873 NM_002160
TNC
tenascin C
chr3_-_31997738 7.768 OSBPL10
oxysterol binding protein-like 10
chr1_+_24518398 7.766 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr6_-_116799548 7.719 LOC100287467
hypothetical LOC100287467
chr21_-_35181956 7.693 RUNX1
runt-related transcription factor 1
chr11_-_119499188 7.604 TRIM29
tripartite motif containing 29
chr17_+_21131940 7.592 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr17_-_7962859 7.568 NM_001165960
ALOXE3
arachidonate lipoxygenase 3
chr11_-_117640407 7.492 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr9_-_109291866 7.450 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr1_-_151788341 7.417 NM_002960
S100A3
S100 calcium binding protein A3
chr1_-_150276064 7.337 S100A11
S100 calcium binding protein A11
chr5_-_1935764 7.319 NM_016358
IRX4
iroquois homeobox 4
chr15_-_58477407 7.271 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr6_+_74462485 7.184 CD109
CD109 molecule
chr17_-_24068759 7.099 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr1_-_150276114 7.076 NM_005620
S100A11
S100 calcium binding protein A11
chr7_-_104696678 6.995 NM_182691
SRPK2
SRSF protein kinase 2
chrX_-_19598912 6.968 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr21_-_35343065 6.953 RUNX1
runt-related transcription factor 1
chr12_-_68369322 6.924 NM_152439
BEST3
bestrophin 3
chrX_+_99785818 6.912 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr17_+_71229110 6.898 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr10_+_123862430 6.864 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_+_71229191 6.832 ITGB4
integrin, beta 4
chr17_+_71229151 6.757 ITGB4
integrin, beta 4
chr3_+_64645819 6.662 LOC100507098
hypothetical LOC100507098
chr6_+_74462226 6.653 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr5_+_36642424 6.605 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_109236897 6.556 NM_003749
IRS2
insulin receptor substrate 2
chr11_+_35596310 6.538 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr15_-_53996597 6.524 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_+_31998269 6.477 NM_001137674
ZNF860
zinc finger protein 860
chr3_-_31998241 6.453 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr6_+_121798443 6.430 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr4_+_81325447 6.327 NM_020226
PRDM8
PR domain containing 8
chrX_-_33139349 6.325 NM_004006
DMD
dystrophin
chr12_-_51912101 6.297 NM_000966
RARG
retinoic acid receptor, gamma
chr16_-_2848106 6.240 NM_022119
PRSS22
protease, serine, 22
chr14_+_62740878 6.198 NM_020663
RHOJ
ras homolog gene family, member J
chr11_+_20005704 6.183 NAV2
neuron navigator 2
chr1_+_151270301 6.170 NM_003125
SPRR1B
small proline-rich protein 1B
chr14_+_95792299 6.120 NM_000710
BDKRB1
bradykinin receptor B1
chr13_+_77007809 6.095 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr7_+_1543644 6.081 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr6_+_83129641 6.062 NM_006670
TPBG
trophoblast glycoprotein
chr18_+_59788242 6.056 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr1_+_44171578 6.045 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr6_+_1556543 5.940 FOXC1
forkhead box C1
chr13_-_29321599 5.770 UBL3
ubiquitin-like 3
chr15_+_38318528 5.668 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_+_74462630 5.650 CD109
CD109 molecule
chr11_+_384238 5.610 PKP3
plakophilin 3
chr1_-_151804929 5.607 NM_005978
S100A2
S100 calcium binding protein A2
chr15_-_68781662 5.596 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_166034402 5.594 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr5_+_35892747 5.553 NM_002185
IL7R
interleukin 7 receptor
chr17_-_3407780 5.533 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr3_-_87122936 5.501 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr11_-_123353607 5.474 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr11_+_12265022 5.466 NM_032867
MICALCL
MICAL C-terminal like
chr3_+_48482213 5.462 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr22_-_30388165 5.417 PISD
phosphatidylserine decarboxylase
chr17_-_36928604 5.380 NM_002275
KRT15
keratin 15
chr6_-_112033775 5.277 TRAF3IP2
TRAF3 interacting protein 2
chr2_-_73170290 5.274 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr5_+_73145098 5.268 RGNEF
190 kDa guanine nucleotide exchange factor
chr11_+_384199 5.263 NM_007183
PKP3
plakophilin 3
chr19_-_48866111 5.250 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr11_-_47502115 5.220 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr6_+_12398514 5.213 NM_001168319
NM_001955
EDN1

endothelin 1

chr16_-_21221872 5.203 NM_001014444
NM_001888
CRYM

crystallin, mu

chr1_+_35019376 5.200 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr1_+_34997928 5.190 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr3_+_190147633 5.176 TPRG1
tumor protein p63 regulated 1
chr2_+_201830998 5.162 NM_001080125
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr4_+_35959638 5.153 NM_001136536
DTHD1
death domain containing 1
chr5_-_141041982 5.135 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_-_105057940 5.088 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr17_-_3408038 5.060 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr5_+_36644187 5.049 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_73911477 5.040 STAMBP
STAM binding protein
chr13_+_75232797 4.978 NM_015842
LMO7
LIM domain 7
chr11_-_2907169 4.976 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr11_+_101423378 4.967 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr6_-_112033752 4.936 TRAF3IP2
TRAF3 interacting protein 2
chr6_+_74462577 4.907 CD109
CD109 molecule
chr17_-_24069299 4.905 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr1_-_150276091 4.887 S100A11
S100 calcium binding protein A11
chr19_-_48661563 4.873 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr2_-_165406098 4.865 COBLL1
COBL-like 1
chr21_-_35343331 4.843 RUNX1
runt-related transcription factor 1
chr17_-_36469869 4.824 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr17_-_37196463 4.816 NM_002230
NM_021991
JUP

junction plakoglobin

chr21_-_35343428 4.767 RUNX1
runt-related transcription factor 1
chr15_+_38923470 4.754 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr5_-_141041933 4.754 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr21_-_26464931 4.702 APP
amyloid beta (A4) precursor protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 5.69e-04 GO:0048856 anatomical structure development
1.35 1.44e-03 GO:0048731 system development
1.68 1.92e-03 GO:0009888 tissue development
1.66 3.50e-03 GO:0016265 death
9.25 4.85e-03 GO:0031581 hemidesmosome assembly
1.65 5.17e-03 GO:0008219 cell death
1.27 5.61e-03 GO:0032502 developmental process
1.56 7.90e-03 GO:0051246 regulation of protein metabolic process
2.19 8.48e-03 GO:0061061 muscle structure development
1.28 1.04e-02 GO:0007275 multicellular organismal development
1.59 1.07e-02 GO:0042127 regulation of cell proliferation
1.48 1.17e-02 GO:0009966 regulation of signal transduction
1.60 1.48e-02 GO:0009611 response to wounding
1.92 1.59e-02 GO:0043086 negative regulation of catalytic activity
1.68 1.69e-02 GO:0006915 apoptosis
3.03 1.82e-02 GO:0032103 positive regulation of response to external stimulus
2.37 2.32e-02 GO:0007517 muscle organ development
5.19 2.52e-02 GO:0032963 collagen metabolic process
1.54 2.67e-02 GO:0010646 regulation of cell communication
1.27 2.87e-02 GO:0007165 signal transduction
1.66 2.90e-02 GO:0012501 programmed cell death
2.52 2.97e-02 GO:0040017 positive regulation of locomotion
1.41 3.70e-02 GO:0023051 regulation of signaling
3.70 3.95e-02 GO:0060326 cell chemotaxis
7.27 4.19e-02 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
2.30 4.41e-02 GO:0008544 epidermis development
2.51 4.78e-02 GO:0030335 positive regulation of cell migration
2.51 4.78e-02 GO:2000147 positive regulation of cell motility
1.76 4.80e-02 GO:0044092 negative regulation of molecular function
1.37 4.87e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 3.54e-04 GO:0005856 cytoskeleton
3.46 7.02e-03 GO:0000502 proteasome complex
1.91 2.56e-02 GO:0005578 proteinaceous extracellular matrix
2.57 3.23e-02 GO:0044449 contractile fiber part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 7.54e-03 GO:0005515 protein binding