Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 5.821


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_748152330.692.9e-03Click!
FOSBchr19_+_506630890.552.6e-02Click!
FOSL1chr11_-_654244360.381.4e-01Click!
JUNDchr19_-_18253436-0.371.6e-01Click!
JUNBchr19_+_12763295-0.048.8e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_19706979 37.088 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_-_177378801 35.212 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_+_181421984 31.719 LAMC2
laminin, gamma 2
chr12_+_13240868 26.448 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240983 25.026 EMP1
epithelial membrane protein 1
chr12_+_13240987 24.884 EMP1
epithelial membrane protein 1
chr1_+_221955876 24.314 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr3_-_152517204 22.809 NM_023915
GPR87
G protein-coupled receptor 87
chr3_+_11153778 22.175 NM_001098213
HRH1
histamine receptor H1
chr7_+_116099648 21.703 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr1_+_181421796 21.652 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr10_-_88720908 21.276 LOC100133190
hypothetical LOC100133190
chr1_+_181422016 20.754 LAMC2
laminin, gamma 2
chr20_-_17487480 19.878 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr10_+_24795465 19.577 KIAA1217
KIAA1217
chr10_+_24795446 19.009 KIAA1217
KIAA1217
chr5_+_145297490 17.451 SH3RF2
SH3 domain containing ring finger 2
chr6_+_47774247 17.122 NM_153838
GPR115
G protein-coupled receptor 115
chr11_+_101488380 16.975 NM_001195045
YAP1
Yes-associated protein 1
chr18_+_59295123 16.939 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
9.25 4.85e-03 GO:0031581 hemidesmosome assembly
7.27 4.19e-02 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
5.19 2.52e-02 GO:0032963 collagen metabolic process
3.70 3.95e-02 GO:0060326 cell chemotaxis
3.03 1.82e-02 GO:0032103 positive regulation of response to external stimulus
2.52 2.97e-02 GO:0040017 positive regulation of locomotion
2.51 4.78e-02 GO:0030335 positive regulation of cell migration
2.51 4.78e-02 GO:2000147 positive regulation of cell motility
2.37 2.32e-02 GO:0007517 muscle organ development
2.30 4.41e-02 GO:0008544 epidermis development
2.19 8.48e-03 GO:0061061 muscle structure development
1.92 1.59e-02 GO:0043086 negative regulation of catalytic activity
1.76 4.80e-02 GO:0044092 negative regulation of molecular function
1.68 1.92e-03 GO:0009888 tissue development
1.68 1.69e-02 GO:0006915 apoptosis
1.66 3.50e-03 GO:0016265 death
1.66 2.90e-02 GO:0012501 programmed cell death
1.65 5.17e-03 GO:0008219 cell death
1.60 1.48e-02 GO:0009611 response to wounding
1.59 1.07e-02 GO:0042127 regulation of cell proliferation

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
3.46 7.02e-03 GO:0000502 proteasome complex
2.57 3.23e-02 GO:0044449 contractile fiber part
1.91 2.56e-02 GO:0005578 proteinaceous extracellular matrix
1.47 3.54e-04 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.15 7.54e-03 GO:0005515 protein binding